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Taking acetaminophen with food may affect how well acetaminophen works for you. It is recommended to take acetaminophen on an empty stomach at least 1 hour. Tylenol (the most common brand of acetaminophen) works much the same way, as do popular prescription analgesics like Clinoril (sulindac), Motrin (ibuprofen). File Format: Microsoft Word - View as HTML Although both ibuprofen and acetaminophen reduce menstrual pain,. Even better, just work out regularly! It Wiki: Twesdg beats looking for the best pain reliever for. Scientists are unsure exactly how acetaminophen works to relieve

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